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Ketoconazole is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Ketoconazole against these fungi and are safer. Thus, Ketoconazole remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Ketoconazole is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Ketoconazole is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Ketoconazole has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

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High doses of ketoconazole are sometimes used to treat Cushing syndrome (a condition that occurs when there is too much corticosteroid hormone in the body) and advanced prostate cancer (cancer of a male reproductive gland). Ketoconazole has not been shown to be safe or effective for these uses. Talk to your doctor about using ketoconazole for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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Initial experience with the use of hypoxic hypoxia in clinical radiotherapy This report describes 144 injuries and 37 deaths in California during the period 1973 through 1975. Pet rodents, such as rats, guinea pigs, and chinchillas, differ from more traditional companion animal species in many aspects of their hematologic parameters. Oral corticosteroids are efficient in recurrent intussusception associated with intestinal lymphoid hyperplasia It is proposed that foci could be populated by infected flies dispersed from the south west, where denser populations exist, on the prevailing winds in the late dry/early rainy season.

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The morphologic changes in the aorta during elastase infusion, which have not previously been investigated, were examined in the rat abdominal aortic aneurysm model. Technical significance of reproducible rectoanal inhibitory reflexes. Significant differences were found in cultures from four of five laboratories that maintained cultures in refrigerators or at ambient temperature. A morpholigical study of an experimental epileptogenic focus in the cat, eighteen months after intracerebral injection of alumina cream, is presented. Tachyphylaxis to histamine was readily demonstrated by repetitive exposure to histamine.

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However, the nature of how interference and RIF are related has not been systematically investigated. Radiotherapy of hypertrophy of pharyngeal lymphatic tissue in children Total alkylated polycyclic aromatic hydrocarbon characterization and quantitative comparison of selected ion monitoring versus full scan gas chromatography/mass spectrometry based on spectral deconvolution. In gastric cancer it would appear that a synergistic effect on response rates has resulted from the combination of methyl-CCNU and 5-FU. The TPHA-test includes not only IgG anti-treponemal antibodies but also IgM antibodies.

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Respiratory movement patterns during vocalizations at 7 and 11 months of age. Potential role of optimal velocity as a qualitative factor of physical functional performance in women aged 72 to 96 years. Proceedings: Education in pathology (report of panel discussion). Upon administration of the agents in this ED50-dose (all agents then being equieffective in their antifibrillatory action) various side effects of each of them were quantitatively measured. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities.

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No signs of increased lymphocytolysis was seen and only after 1--2 weeks treatment with a long acting corticosteroid was the thymic cortex reduced and thymic weight decreased. Residual host proteins may identify sources of infection for ticks. Specifically, it is important to reconcile the different hypotheses of Hb toxicity, such as nitric oxide (NO) depletion and oxidative reactions, to provide a coherent molecular basis for designing a safe HBOC. In this paper a series of twelve families with several cases in each one is reported.

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Membrane vesicles isolated from cells of bacillus subtilis W23 accumulate manganese in the presence of an energy source. Midline crossing by dI1c axons is lost in Lhx2/9 double mutants, a defect that results from loss of expression of Rig-1 from dI1c axons. Two reviewers independently extracted and entered data into RevMan (Cochrane Collaboration software).

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The novel way by which this was achieved involved inserting in frame the 16-amino-acid self-cleaving 2A protease of foot-and-mouth disease virus between the CAT and the NA coding sequences. A novel and highly efficient system for chalcopyrite bioleaching by mixed strains of Acidithiobacillus.

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Colorectal cancer risk factors among the population of South-East Siberia: a case-control study. Neuropathological examination of six brains of newborns and infants who died in the course of congenital cyanotic cardiac anomalies showed focal brain lesions. Surprisingly, rapid DC maturation results in early failure and delay in MHCII presentation. The immune response was increased when chemosignals was loadeded for 1-10 days after immunization.

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Primary cultures of freshly isolated rat inner medullary fibroblasts were established as reported previously. We must be aware of the rare pulmonary manifestation of amebiasis.

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Moreover, ephrin-A5 and B1 differentially influenced actin reorganization. The procedure gives a high yield of pure human lymphocytes from small amounts of blood, good preservation of B cell/T cell ratio, and sufficient material for subsequent biochemical studies.

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Fluctuations in the levels of sex steroid hormones begin at menarche and end with menopause in the human female. The extent of absorption of sulfisoxazole acetyl was not affected by the amount of triolein in which it was administered nor by emulsification of triolein prior to administration. This case of small cell lung cancer appeared in chest radiographs to have an unusual shape. In this paper we describe an exemplary integration of an existing standalone scoring system for acute abdominal pain into two different commercial hospital information systems using Java/Corba technolgy. Mice lacking 11beta-HSD-1, however, show a more subtle phenotype with reduced activation of glucocorticoid-induced processes.

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Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. The potential clinical significance of these findings is pointed out.

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Despite major advances in our understanding of pneumococcal pathogenesis, the need for vaccines and antibiotics to combat this pathogen is still vital. This notice sets forth the names, addresses, service areas or modified service areas, and dates of qualification or expansion of entities determined to be Federally qualified health maintenance organizations (FQHMOs) during the period January 1, 1994 through March 31, 1994.

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Expression of the chimeric receptor between the chitin elicitor receptor CEBiP and the receptor-like protein kinase Pi-d2 leads to enhanced responses to the chitin elicitor and disease resistance against Magnaporthe oryzae in rice. Modification of the motor function of the stomach in artificial pneumothorax In 5 cases operative dorsal pancreatography was performed: it was normal in all cases. The effect of bencyclane on the oxidative phosphorylation in isolated mitochondria of heart and liver. In the presence of molecular oxygen, the colorless metabolite leukomethylene blue is readily oxidized to methylene blue, thus explaining the visible color change of the myocardium.

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Close to desperation, this doctor found the perfect caretaker for her children. For proton, hydride, and proton-coupled electron transfer reactions, typically the donor and acceptor become closer to facilitate the transfer. On this basis, the term, the Sexually Dimorphic Nucleus of the Preoptic Area (SDN-POA) is proposed, for this region. Nuclear magnetic resonance spectroscopy has been used to investigate the solution conformation of tuftsin, threonyllysylprolylarginine, as well as a pentapeptide inhibitor of tuftsin, threonyllysylprolylprolylarginine.

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Excitation at the synapse: Eph receptors team up with NMDA receptors. The results of our study suggest that Sindbis virus (SINV) infection in BHK-21 cells leads to the formation of at least two types of nsP3-containing complexes, one of which was found in association with the plasma membrane and endosome-like vesicles, while the second was coisolated with cell nuclei. Complex V of plant mitochondria--another target for agrochemicals? The EuroQol is a generic questionnaire developed to provide a simple method for assigning utility values to health.

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Burdenko - a prominent Soviet scientist, surgeon and organizer of medical science Antibacterial properties of fish mucus from Channa punctatus and Cirrhinus mrigala. However, a recent study of VLBW children in 3 health maintenance organizations found no significant delays in immunizations.

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Patients who developed coupled contractions had a longer duration of labour, a higher uterine activity integral and an increased incidence of caesarean section for failure to progress. Growth of new nociceptors, activation of nociceptors in the subchondral bone exposed after cartilage degradation, and nociceptors innervating synovium sensitized by inflammatory mediators could all augment the peripheral input to the central nervous system and result in pain. Rat kidney metallothionein induced by injection of Cd-thionein: Changes of chromatographic properties with time and their relation to copper content and kidney dysfunction.

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The nanostructure and nanomechanical properties of aggrecan monomers extracted and purified from human articular cartilage from donors of different ages (newborn, 29 and 38 year old) were directly visualized and quantified via atomic force microscopy (AFM)-based imaging and force spectroscopy. The histology is discussed and it is suggested that the drug should not be given in the presence of suspected hepatic dysfunction. These cells may represent a prothymocyte population, which, on malignant transformation, may give rise to acute lymphoblastic leukaemia, and to some cases of chronic granulocytic leukaemia in the blastic phase. Aldrin epoxidation, a highly sensitive indicator specific for cytochrome P-450-dependent mono-oxygenase activities.

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We examined six male and six female subjects by functional magnetic resonance imaging (fMRI) to image cortical activation patterns associated with cognitive and motor activation to determine whether these changes during the menstrual cycle can be visualized. Tubular water reabsorption as a viability indicator in the preserved canine kidney.

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Changes in left ventricular function after cardiac arrest and reperfusion in hypertropheral hearts. Therapeutic effectiveness of diphetarsone in the treatment of trichocephaliasis To elucidate a potential combined dietary and exercise intervention affect on cardiovascular risk reduction of the National Aeronautics and Space Administration Headquarters employees.

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Effect of coal ash on methylmercury in historically contaminated river sediments. Rapid detection of 3500Q and 3531 mutations and MspI polymorphism in exon 26 at the apolipoprotein B gene.

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