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Dutagen (Dutasteride)
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Dutasteride

Dutagen, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Dutagen is generally safe and well tolerated. Dutagen has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Dutagen may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Dutagen is used alone or with another medication (tamsulosin [Flomax]) to treat benign prostatic hyperplasia (BPH; enlargement of the prostate gland). Dutagen is used to treat symptoms of BPH and may reduce the chance of developing acute urinary retention (sudden inability to urinate). Dutagen may also decrease the chance that prostate surgery will be needed. Dutagen is in a class of medications called 5-alpha reductase inhibitors. It works by blocking the production of a natural substance that enlarges the prostate.

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The study of the consistency of a number of semi-solid pharmaceutical preparation, namely: simple ointment base, paraffin ointment base, emulsifying ointment base and soft paraffin (m.p. Cystic fibrosis of the pancreas was established as the cause of the disease and of the biliary cirrhosis.

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Thr relationship of nitrogen metabolism in Diplodia maydis to Zea mays L. Primary lymphoma of the stomach: review of the literature and presentation of 5 cases

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Anti-cancer, anti-inflammatory and anti-microbial activities of plant extracts used against hematological tumors in traditional medicine of Jordan. Thermostat storing of tins for 5--6 day-and-night periods at 37 degrees C makes it possible to detect all tins that are nonsterile. Batten disease: ocular features, differential diagnosis and diagnosis by enzyme analysis. Sprague-Dawley rat pups at 7 days old were isolated from their dam, then the number of vocalizations was measured for 5 min. To date, there is no form of treatment that has been proven to prevent the onset of preterm labor.

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The advent of implantable devices allows the performance of clinical trials with a mortality endpoint in patients with manifest ventricular tachycardia and fibrillation while providing an alternative mode of therapy for these arrhythmias. Exposure of C-6 glial cells of NE at various dose for 60 minutes stimulated the efficiency of 3H-leucine corporation into protein. A VTE episode does not significantly increase the risk of MI, but does increase the risk of death, particularly in the first year following VTE diagnosis.

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Significant cell growth inhibition was observed in the presence of 1.2g/L (higher concentration) bile salts. A better understanding of such factors may lead to more effective promotion of trail use. The effect of fibroblast conditioned medium on neutrophil survival and activation.

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In this study we demonstrate that PTX-B profoundly impairs entry and replication of the HIV-1(ADA) (R5), as well as of HIV pseudotyped with either murine leukemia virus or vesicular stomatitis virus envelopes, in primary monocyte-derived macrophages. Mindless eating challenge: retention, weight outcomes, and barriers for changes in a public web-based healthy eating and weight loss program. Marfan syndrome with ascending aortic aneurysm: value of cardiac computed tomography. The mechanisms proposed for the formation of the prominent ions in these spectra have been confirmed with the aid of deuterium labelling, measurements on metastable ion decompositions, low eV spectra and high resolution mass measurements.

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Centre for Reproductive Medicine, which is a tertiary referral institution. Skin reactions to the synthetic cleansing substances teepol, arysulfonate and lissapol After binding, alemtuzumab causes profound and durable depletion and has been successfully used as immune induction therapy for organ transplantation.

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Infants were randomised within 48 h of birth to a developmental care (DC) or standard care (C) group. They also show the level of student confidence and the services used.

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Compare the effect of different chemical methods for preparation of acellular nerve scaffold and to provide an effective nerve scaffold for tissue engineering. A variety of disinfectants was tested against, their efficacy against Rabies virus Flury LEP strain. It was compared to two other algorithms using a correction for changes in lung gas stores between two successive breaths (AU, W) and one without correction (NC).

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To examine viral evolutionary changes and their relationship to hepatitis B e antigen (HBeAg) seroconversion. Identification and characterization of the historical dynamics of the conserved sites have relevance to multiple applications, including potential targets for diagnosis, and prophylactic and therapeutic purposes. PSA at diagnosis, biopsy Gleason score and the percent of positive biopsies are important predictors of under staging.

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Deendothelialized rings of rabbit aorta relax after exposure to UV light because of release of a relaxing factor that is similar if not identical to nitric oxide. In BIH the CSF flows were not different from those of normal volunteers. The localization of multiples proteins, whose function are disrupted in PKD, in the primary cilium or at basal body at the base of the cilium highlight this neglected organelle as a common trigger of cystic diseases.

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The regions important for channel size were localized to amino acids 127-195 of LcrV and to amino acids 106-173 of PcrV. Among experienced abdominal radiologists, similar diagnostic performance in polyp detection was found among 2D multiplanar reformation and 3D display techniques, although individual cases showed improved characterization with 3D display techniques. The aim of the study was to determine whether ADC measurements allow discrimination of diffuse large B-cell lymphoma (DLBCL) from follicular lymphoma (FL), and to examine the relationship between cellularity and ADC value of the tumor using DWI.

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Diagnosis and treatment of isolated processes of the middle lobe No change in regional expression patterns was seen in response to the altered luminal environment by any of the enterocytic markers and four of the five enteroendocrine cell subpopulation markers. In order to estimate inter- and intra-individual variability in fat tissue blood flow with exercise, a population PBPK model for toluene was fitted to experimental data from subjects exposed to toluene vapors (Carlsson, A., 1982.

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They completed health status measures and a clinical test of sleepiness. To promote the most efficient projects, they have to be evaluated with respect to their contribution to the goals of waste management. A comparative idiotypic antigenic analysis of an IgMlambda and an IgGkappa paraprotein obtained from sera of an individual patient, Br, revealed the presence of very similar idiotypic determinants associated with the VH regions of the Br mu- and gamma-chains.

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Median loss of blood at operation was 17 ml in those given Dicynene compared with 72 ml in the placebo group (p equals less than 0.001). Comparisons between hog intestinal peroxidase and bovine lactoperoxidase-compound I formation and inhibition by benzhydroxamic acid.

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Possibilities in the use of prostaglandin antagonists in early pregnancy (proceedings) Complete recovery of renal function occurred, but proteinuria recurred, responding to a course of steroids. The integration of inpatient treatment and transitional day hospital: application of a problem-solving approach. Here we review the analytical potential of CE for the determination of a wide range of lipids. Pseudomembranous entercolitis after antibiotic treatment: vancomycin therapy

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Previous studies have also shown no correlation between HCV seropositivity and the presence of HCV RNA in the corneal tissues. We studied stereopsis and color vision in patients with right extrastriate cerebral lesions. This new inhibitor is chemically quite different from cromoglycate and shows qualitative and quantitative advantages over it. Demonstration of hemoglobin and stroma stain in erythrocytes during staining of blood smears according to Pappenheim Tocopherols and tocotrienols are part of an interlinking set of antioxidant cycles, which has been termed the antioxidant network.

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The effects of intra-arterial bleomycin therapy on squamous cell carcinoma of the oral cavity. Frequency-dependence of the metabolism of 3H-noradrenaline released from rabbit isolated aorta: effects of a combination of cocaine and corticosterone or hydrocortisone. To assess the within-session reliability of the Modified Functional Reach Test (MFRT) and the Timed Up and Go (TUG) test in children with traumatic brain injury (TBI) and children with typical development (TD). Areas of interstitial pneumosclerosis, atelectasis and carnification were found to have a high STmin and to contain less than 1 mg of PL per 1 g of the lung tissue, whereas foci of emphysema had a lower STmin and a higher content of PL. The ways in which rehabilitative surgery can improve function and retard further damage are discussed in the light of the pathogenesis of disability due to intraarticular and intramuscular hemorrhage.

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However, the multifactor theory of the EEM recently proposed that cognitive characteristics of emotional stimuli, e.g., relatedness and distinctiveness, also play an important role. A second group of type A neurons in the NA responded to fentanyl by a reduction in firing rates.

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The primary purpose of this project was to ascertain the effects of load misalignment on the calculated stresses within the cement layer. HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland. Antineoplastic agents: comparing off-label uses among authoritative drug compendia. As MR imaging is applied further to cellular and molecular imaging (e.g., imaging of gene transfer and expression), more possibilities for brain tumor diagnosis and treatment will become evident. Effect of novocain block on blood supply and capillary permeability in inflammation

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Enzyme assay for 5alpha-reductase type 2 activity in the presence of 5alpha-reductase type 1 activity in rat testis. It is clear that patients for whom compliance with the procedure is most deficient are those who have fewer arterial pressure recordings as well as those receiving no drugs treatment.

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This study examines the issues associated with enhancing the representation of rural areas in the National Medical Expenditure Survey (NMES). Carotid endarterectomy is the operative procedure of choice, since there may be startling apparent increase in size of the arterial lumen distal to the surgical repair. Liquid-chromatographic assay for urinary homovanillic acid, with fluorescent detection. A comparison of caudal epidural bupivacaine with adrenaline and bupivacaine with adrenaline and pethidine for operative and postoperative analgesia in infants and children.

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The audit can either be an ad hoc occurrence or part of a scheduled programme of examination and can be initiated by a specific concern, review of good practice or a process of change. We investigated the predictive validity of commonly used application blank items as measures of future performance, absenteeism, tardiness, and tenure (the criterion variables) among 100 hospital-employed respiratory therapists and looked at the relationships among the criterion variables. (6) What issues related to outcomes should be considered in the evidence review? Social exploration was decreased 2 and 4 h after injection of TNF and IL-1, but body weight was not affected. Both effects were blocked by pretreatment with desipramine, a NA uptake blocking agent.

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Interictal proton (1H) MRS is increasingly used for seizure lateralization in patients with temporal lobe epilepsy (TLE). It is shown that lipid peroxides are involved in damaging erythrocytic membrane structure and function, thus promoting the progression of ischemic heart disease. Administrative simplification eases the billing and payment process.

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Critical reading aptitude of clinical research texts in teaching specialist doctors The proposed networks would provide a full continuum of services from prevention through aftercare and long-term care, and from primary through tertiary care. Selective sequestration of iridoid glycosides from their host plants in Longitarsus flea beetles. Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness. Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts.

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Truncus arteriosus communis with possible absence of the right pulmonary artery. Tegmental defects were confirmed at surgery in all cases, demonstrating meningocele or arachnoid granulations in 2/5 and encephalocele in 2/5 patients. H3 and the mutant variants selected with mAbs 36.2.2 (H3-36) and 54.2.8 (H3-54) induced severe myocarditis in DBA/2 (H-2d) and A/J (H-2a) male mice, whereas CBA (H-2k) mice were disease resistant. Bestrophin protein was readily detectable by Western blot in CEM replacement medium whereas it was barely detectable in DMEM/F12 and undetectable in DMEM with high and low glucose. Other useful biomarker proteins include other serine hydrolases, albumin, tubulin and transferrin.

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We interpret the measurements in terms of feedback-induced dynamics, compare them with the results from a stability analysis model for conventional feedback, and find good qualitative agreement. However, favorable improvements in each of the 3 markers were associated with improved clinical outcomes at 60 days. On the basis of this scheme the finer details of the process are being elucidated.

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A quantitative description of heterotrophic growth in micro-organisms. Two cortical areas mediate multisensory integration in superior colliculus neurons. We identified 6585 MS index cases and 2509 spousal controls with preterm birth information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Since the efficacy of antidepressants is highly age-dependent, we studied possible age-related effects of TMS on hippocampal evoked responses.

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Second, we cloned the hairy orthologue from Tribolium confusum and show that its expression mimics that of Tribolium castaneum, implying that stripe expression should be functional in some way. Four Amblyomma sabanerae ticks collected from a turtle (Kinosternon sp.) in San Miguel, El Salvador, were found by molecular analysis to be infected by Rickettsia bellii. The results of the free description method have psychological as well as psychopharmacological plausibility. Stimulated production of slow reacting substances by mercaptans from ionophore A 23187-induced mononuclear cells: mercaptan structure-activity studies.

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A combination of the BEACOPP-14 polychemotherapy regimen and imatinib induced no severe complications. We have built a pyrometer in the IR range and expanded the lower limit of temperature detection to 400 K. More recently, machine learning methods have been applied for developing tools capable of predicting diverse spectrum of compounds of different toxicological properties and ADR profiles. Of those affected with this condition, approximately one third have symptoms severe enough to require medical therapy.

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These results support the concept of a natural immunosurveillance mechanism against leukemia or lymphoma development in an outbred mammalian species. This article reports on the potential use of adenosine triphosphate bioluminescence for fast and highly sensitive biocompatibility screening. The findings that microglial mRNA expression of proglucagon and GLP-1 protein expression are affected by high levels of free fatty acids and that both mRNA expression levels of proglucagon and secretion levels of GLP-1 are affected by inflammatory stimuli could be of pathogenic importance for the premature neurodegeneration and cognitive decline commonly seen in T2D patients, and they may also be harnessed to advantage in therapeutic efforts to prevent or treat such disorders. The current treatment tactics, therapeutic schemes according to the stage and follow-up corresponding to the requirements of the oncological doctrine are present.

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At the time of neuroma relocation we noted that the vein was intact around the ulnar nerve and that there was no scarring between the vein and nerve. Theory and experiment examining electron transfer through molecules bound to electrodes are increasingly focused on quantities that are conceptually far removed from current chemical understanding. Their stability, biocompatibility, and small size offer the promise of nontoxic, sensitive high-resolution biological imaging.

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Bullets fired from hand guns are often partially or fully jacketed with copper - a fact that can usually be recognized on radiographs. Epidemiology of human encounters with the spitting cobra, Naja nigricollis, in the Malumfashi area of northern Nigeria. Measurement of the pool size and synthesis rate of the metabolically unstable fraction of RNA in Escherichia coli by a method independent of hybridization efficiency and unaffected by precursor compartmentation. Mutants of Klebsiella pneumoniae resistant to several antibiotics. The continuous bubbling OMCB treatment was more effective than the non-bubbling OMCB treatments at reducing the FT and benomyl agricultural pesticide residues from both the red and green persimmon leaves.

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Respondents used faculty members for support less frequently than they used their peers, spouse/significant other or parents. These observations suggest that the acceleration of shortening of the ventricular radius reflects ventricular performance more closely than does the rate of shortening of the radius. Paraffin section immunohistochemistry (IHC) is widely used in diagnostic surgical pathology.

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Epidural versus intravenous fentanyl metronidazole oral liquid for dogs for reducing hormonal, metabolic, and physiologic responses after thoracotomy. The implementation of a treatment pathway brought about a robust change in process-related variables. Isolates on the whole were resistant to penicillin and ampicillin (five of six isolates) and sensitive to rifampin and streptomycin (six of six isolates). The following AAC assessment personnel are discussed: AAC finders, general practice SLPs, AAC clinical specialists, facilitators and communication partners, collaborating professionals, AAC research and policy specialists, manufacturers and vendors, funding agencies and personnel, and AAC/assistive technology agencies and personnel. Echocardiographic evaluation of pulmonary hypertension by oxygen inhalation method.

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We studied the rates at which solid and liquid leave oxybutynin patches or tablets the stomach after meals of wholemeal and white bread by using a double isotope technique. In eighteen normal healthy volunteers, the effect of cigarette smoking, coffee drinking and alcohol consumption on adrenomedullary sympathetic function was assessed in terms of urinary VMA levels. The significance of heart insufficiency in central conduction anesthesia This review article is about some recent developments in quality assurance in health care. Use of permethrin as a miticide in the African hedgehog (Atelerix albiventris).

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The erythrocyte binding motif of plasmodium vivax duffy meprazol drug binding protein is highly polymorphic and functionally conserved in isolates from Papua New Guinea. Dietary planning seems to play a role in the mechanism that facilitates fruit intake among Iranian women. Comparison of buccal and nasal epithelial cells using a new cell development index and quantitative interference microscopy. Lysosomal acid cholesteryl esterase activity in normal and lipid-laden aortic cells.

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High-risk males reported higher mean levels of quarrelsome behaviour and lower mean terazosin side effects insomnia movie levels of agreeable behaviour than high-risk females, whereas low-risk males and females reported comparable levels of affiliative behaviours. Experimental results show that the fully continuous, real 3D scene pick-up and display system is feasible with a throughput of 8 fps in real time. Such adverse effects were not found in rats receiving cloxacillin. There was no clinical indication of familial lipodosis in either case.

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The increasing mobility within countries and migration mechanism of action of class iii antiarrhythmic drugs amiodarone across borders affects the growing prevalence of HIV, but little is understood about how migrant women view risk of HIV in relation to pregnancy. Applying the rule-of-two is an appropriate means of estimating risk for DILI compared with dose alone.