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Lamotrigina (Lamotrigine)
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Lamotrigine

Lamotrigina is an important anticonvulsant with activity against both focal and generalized onset seizures. It is also effective in the treatment of bipolar disorder and neuropathic pain. However, its use is associated with a significant incidence of adverse cutaneous reactions, mainly when concomitant therapy is administered. Rash is the most common adverse reaction of this antiepileptic agent and the most common reason for treatment discontinuation as it can be life-threatening. Children under polytherapy have a higher risk of this adverse event. Such cutaneous reactions range from mild rashes to more serious conditions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis. SJS is thought to be a hypersensitivity reaction involving skin and mucous membranes.

Other names for this medication:
Lamotrigine, Lamictal, Daksol, Epitec, Flamus, Labileno, Lafigin, Lamal, Lambipol, Lamez, Lamictin, Lamidus, Lamirax, Lamitor, Lamitrin, Lamogine, Lamolep, Lamotrigin, Lamotrigina, Lamotrix, Lomarin, Meganox,

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Lamotrigina comes as a tablet, an extended-release tablet, an orally disintegrating tablet (dissolves in the mouth and can be swallowed without water), and a chewable dispersible (can be chewed or dissolved in liquid) tablet to take by mouth with or without food. The extended-release tablets are taken once a day. The tablets, orally disintegrating tablets, and chewable dispersible tablets are usually taken once or twice a day, but may be taken once every other day at the beginning of treatment. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand.

There are other medications that have names similar to the brand name for Lamotrigina. You should be sure that you receive Lamotrigina and not one of the similar medications each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given Lamotrigina. After you receive your medication, compare the tablets to the pictures in the manufacturer's patient information sheet. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Swallow the tablets and extended-release tablets whole; do not split, chew, or crush them.

If you are taking the chewable dispersible tablets, you may swallow them whole, chew them, or dissolve them in liquid. If you chew the tablets, drink a small amount of water or diluted fruit juice afterward to wash down the medication. To dissolve the tablets in liquid, place 1 teaspoon (5 mL) of water or diluted fruit juice in a glass. Place the tablet in the liquid and wait 1 minute to allow it to dissolve. Then swirl the liquid and drink all of it immediately. Do not try to divide a single tablet to be used for more than one dose.

To take an orally disintegrating tablet, place it on your tongue and move it around in your mouth. Wait a short time for the tablet to dissolve, and then swallow it with or without water.

If your medication comes in a blisterpack, check the blisterpack before you take your first dose. Do not use any of the medication from the pack if any of the blisters are torn, broken, or do not contain tablets.

If you were taking another medication to treat seizures and are switching to Lamotrigina, your doctor will gradually decrease your dose of the other medication and gradually increase your dose of Lamotrigina. Follow these directions carefully and ask your doctor or pharmacist if you have questions about how much of each medication you should take.

Lamotrigina may control your condition, but it will not cure it. It may take several weeks for you to feel the full benefit of Lamotrigina. Continue to take Lamotrigina even if you feel well. Do not stop taking Lamotrigina without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. Your doctor will probably decrease your dose gradually. If you suddenly stop taking Lamotrigina, you may experience seizures. If you do stop taking Lamotrigina for any reason, do not start taking it again without talking to your doctor.

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